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Anyone had Lonsurf (trifluridine-tipiracil) for pancreatic cancer?

Pancreatic Cancer | Last Active: Feb 13 7:05am | Replies (7)
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@gamaryanne

Hello, where are you being treated for your pancreatic cancer with Lonsurf? Wondering, because this has not come up as an option for me or others I know.

Thank you for your reply.

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Replies to "Hello, where are you being treated for your pancreatic cancer with Lonsurf? Wondering, because this has..."
stageivsurvivor | @stageivsurvivor | Feb 3 9:53am

Lonsurf can be used as off-label treatment as it has FDA approval. There was research at the NCI in a pancreatic cancer mouse model combining it with the PARP inhibitor Talazoparib (Talzenna) showing effectiveness. The Lonsurf damages the DNA and the Talzenna prevents the malignant cells from repairing DNA inducing apoptosis. Currently there is a clinical trial phase I dose escalation study at Roswell Park Cancer Institute in Buffalo, NY recruiting patients with esophageal junction and colorectal cancers. If the dose escalation study is successful, the next phase plans to enroll Pancretic cancer patients.
https://www.cancer.gov/news-events/cancer-currents-blog/2024/lonsurf-talzenna-cancer-tp53-mutations?utm_source=chatgpt.com

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harveyandshari | @harveyandshari | Feb 3 11:14am

I am being treated at the lavine cancer center in Charlotte NC. I have had 30 chemo treatments so far. It’s been a long journey.

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