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Anyone seen research on long term Proton Pump Inhibitor use and PN?

Neuropathy | Last Active: May 13 3:58am | Replies (37)
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@johnbishop

Welcome @maximas, Sorry to hear you are having pins and needles neuropathy symptoms in your hands and feet. There is some evidence that PPIs can cause the symptoms. Here's one of many references.
-- How can proton pump inhibitors damage central and peripheral nervous systems?
https://pmc.ncbi.nlm.nih.gov/articles/PMC7716020/
There is another discussion on the topic that you might find helpful to connect with others that share the same symptoms from PPIs.
-- Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?
https://connect.mayoclinic.org/discussion/neuropathy-and-ppi-use-has-anyone-had-this-experience/
Have you discussed the symptoms with your doctor or care team to see if there might be some alternatives?

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Replies to "Welcome @maximas, Sorry to hear you are having pins and needles neuropathy symptoms in your hands..."
maximas | @maximas | Feb 4 5:40am

I started getting the tingling in hands and feet after +1-year on them - I decided to give them up - did so for around 4/5 months and symptoms disappeared - then went back on PPIs and have been on since (2020) and started getting tiredness/fatigue and now Neuropathy has returned - B12 was borderline in July and ok in November but I hear that this doesn't verify Functional B12???

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