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Tips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)
Depression & Anxiety | Last Active: 2 days ago | Replies (6296)Comment receiving replies
I have suffered from major depression most of my life. I'm currently going through withdrawals from Effexor, while starting Trintellix.
I'm at my wits end with feeling awful, even woke up with numbness in my right hip and leg, and a little in my right arm.
I believe I am at my lowest point ever, in terms of depression. I don't know what to do anymore. But cry...and I can't even do that, but feel like it.
Replies to "I have suffered from major depression most of my life. I'm currently going through withdrawals from..."
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You don't mention if you tapered off Effexor and then tapered on to Trintellix. Read all the posts here for helpful information about getting off Effexor.
You can read the manufacturer's info about Trintellix here--https://www.lundbeck.com/upload/ca/en/files/pdf/pi/Trintellix.pdf.
Numbness was not listed as a side effect, but "Low sodium level in blood causing symptoms of tiredness, weakness, confusion combined with achy, stiff, or uncoordinated muscles" is listed as a rare side effect that you should talk with your doctor, or pharmacist about. In any case, talk to your doctor and/or pharmacist about feeling awful and the numbness.
I found this article on switching between two anti-depressants--https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919171/. Table 3 gives the strategy for switching from various drugs to another; for Effexor, go down to the sixth drug and go right to the fourth column for Trintellix (vortioxetine).
I also found this site where folks going from Effexor to Trintellix commented--https://www.reddit.com/r/depressionregimens/comments/8kxlrj/effexor_withdrawal_trintellix/.