Well, ladies, I have begun my journey off of Prolia. After a really helpful consultation with Mayo in Rochester in January, and their reassurance that they have transitioned a variety of women off of Prolia, I decided to go on Alendronate for 3 months. My CTX before alendronate was at 145 at the 6 month and 16th day following the 5th injection of Prolia. In 3 months I will have another CTX. test. Based on that number my team will decide the next step. You all may be aware that Zoledronic acid requires a certain amount of bone turnover to be effective. My hope and prayer is that I am one of those who can tolerate the medications well and will have no more VFs. My decision was aided by being able to have a great discussion about the research I had studied along with their expert explanation about following this course of action for 3 month. Reclast can be administered after alendronate should my numbers significantly rise ( I am hoping not). As all of you know NONE of this is easy. I just finished my first month of Alendronate. I will keep you posted.