good! I'm on a low dose currently but it really has reduced the pins,needles and burning. Has not helped the numbness in my toes but the horrible pain is much better. Duloxetine ( brand name Cymbalta) is an anti depressant by development but it helps with neuropathy pain. I've also suffered light headedness/dizziness with my neuropathy and I believe this is also starting to make me feel less like a bobble head. Crossing fingers.