Chemotherapy caused neuropathy in my hands and feet, although it's been much less severe in the hands than the feet. I took part in a research project that involved exercising regularly to see if it improved the neuropathy. It might have. At the same time, I was determined to keep up my guitar playing, and did. My conclusion is that the more intensive hand exercise with the guitar is highly effective in reducing the numbness and discomfort. If it weren't so damned cold these days, I'd be going barefoot to maximize the exercise and stimulation of my feet.