I was on 375mg of effexor daily for about 7 years. I started weaning about a month ago going down by 37.5mg every five days. Once I was down to 75mg my doctor started me on Trintellix, 5mg a day. I am now at 37.5mg of effexor and 5mg of Trintellix. I have had a migraine every day this week. The brain zaps you talk of happen in the evening. And my anxiety also increases in the evening. I have 4 days of the effexor left. So far, I think I'm doing pretty good. Just trying to find the cause of this endless headache. I do have a prescribed migraine med that I take, so it is manageable. Hoping things will be back to "normal" in the next couple of weeks. I go up to 10mg of the trintellix in about 6 weeks.