Mayo Clinic comes to mind; perhaps one of the moderators can give you info on that since it is quite a ways from you. Methotrexate does have side effects when one is on the meds. They go away once off the med. If your reaction is severe enough, ask your doctor if the dosage could be decreased. Aerobic exercise might be out, particularly with the fatigue, but you might still be able to do resistance/stretching. If your rheumatologist could give you a ref for PT to strengthen your muscles, that helps some with the depression and fatigue. Here are some potential side effects (for me it was mostly fatigue, balance, and slight nausea): https://my.clevelandclinic.org/health/drugs/20143-methotrexate