Try not to panic. 346 is not an ohmygod number. You can live a normal life with that. I have a 205 and I still go jogging with my cardiologist's blessing.

If you've been on a statin, that would have calcified existing soft plaque, which is good but will raise your score. The scan measures calcified plaque,not soft plaque, so if the statin does that, by definition it has raised your score. Soft plaque is dangerous because it can break off and cause a clot. Calcified plaque is much more stable.

This isn't a sudden condition. If you had taken that test ten years ago, it probably still would be a non-zero result. You just didn't know it. The statin has helped prevent further buildup.

Your cardiologist may want to do an angiogram just to get in there and check it out. He may increase your statin dose so that you can get your LDL even lower. And you should pay attention to your diet if you're not already.

If you had a major blockage, you'd probably have noticed some symptoms by now.