I’ve posted before about my Zometa experience but in a nutshell: in 2022, at 70, active lifestyle, maybe 10 pounds overweight, first infusion 3 months after finishing radiation. No apparent side effects. Second infusion, 6 months later. With 10 days, mid-thigh leg pain on the infusion side. Became significantly worse and 4-5 months later, debilitating. Truly difficult to walk. Initial attributed it to a chiropractic issue but realized it was a textbook zometa effect. Refused future treatments. However, my recent bone density scan a few months ago shows I did go from osteopenia to normal ranges, so there’s the proof that it works!