Hi @bharden - In a previous PET scan, I had an indication of hypermetabolic intake of 2.4 SUV (standard uptake value), which the radiologist characterized as mild metabolic activity. I believe whether hypermetabolic activity is greater than mild is defined by its SUV. I don't know what those values are. According to A. Mendelson, MD, on this webpage titled "What is SUV on PET Scan," https://radiologyinplainenglish.com/what-is-suv-on-pet-scan/ SUVs greater than 2.5 raise concern for cancer, but may not indicate cancer. As @colleenyoung mentions in her December 10, 2022 post, in addition to cancer, hypermetabolic activity could indicate lymph node infection or inflammation. The PET scan can't tell the difference, therefore consult your doctor to help make that determination.