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@hungrybirder

Dear ekarasoulis59,
78 here and on bisphosphonates 7 years followed by a long drug holiday. Had to go back on the bisphosphonates in 2021 and wondered if the drug holiday sort of "reset" things.
Just recently I discovered this Mayo Press article addressing just that; it's from January 2024 so should reflect current thinking.
The paragraph I found interesting follows:

The optimal duration of oral bisphosphonate therapy is typically 5 to 10 years, and for intravenous (IV) bisphosphonates it’s 3 to 6 years. This varies based on your individual fracture risk at one time. Beyond this, a “drug holiday” or withdrawal period is recommended to prevent harmful accumulation of the medicine. After this break, bisphosphonates are often resumed without long-term complications, after proper time lapsed for the natural remodeling process to reset and function normally.

It addressed the length of the holiday later in the article which you can read at:
https://mcpress.mayoclinic.org/healthy-aging/taking-a-break-from-osteoporosis-medicine-what-you-need-to-know/

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Thanks for sharing