Received MRI Results Today

Posted by stew80 @stew80, Nov 30, 2024

Hi Brothers,
My high PSA numbers (~ 12) led to me getting an MRI last week. Today I have the results and they are concerning. The highlights are:
One large lesion 2.7 x 1.7 x 2.5 cm in left peripheral zone.
One smaller lesion (0.8 cm) in right anterior mid-gland.
No lymphadenopathy.
No suspicious bone lesions.
PSA density is 0.45.
I'm not sure what this all means and I'm in a bit of a shock. I just wonder if anyone has had a similar diagnosis. I would appreciate any comments or opinions. I haven't had a medical consultation yet so the grading is not identified. I'm 84 and otherwise very healthy and active.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

@mac44

I am researching radiation treatment for prostate cancer. I have an intermediate case and was advised by my Urologist to meet with radiation oncologists due to my age. Has anyone been treated with Cyberknife or HIFU (high intensity focused ultrasound) and, if so, I would appreciate hearing about your outcomes, including side effects like incontinence and ED. Thank you

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My brother had CyberKnife SBRT on his prostate two years ago and has been clear since then. The only problems he had were some urinary issues which were solved by taking flowmax for a few months.

You didn’t supply enough information to really get the best feedback. What was your Gleason score, What was your PSA when you had a biopsy? Was anything else found in your biopsy that you don’t mention? All of these things can be a factor in what your decision should be.

I’ve had CyberKnife to my spine to remove a metastasis. I’ve had seven weeks of radiation to my prostate bed, After surgery failed. I had absolutely no side effects to either one of those radiation treatments. Some people do have reactions, I just never had any.

You may have multiple choices, Here are some more non-radiation treatments. Cyberknife SBRT , HIFU , NanoKnife , Cryotherapy and TULSA-PRO. Many people in this forum have had Tulsa Pro and really like the results.

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Thank you for your information on cyber knife outcomes and your questions. My PSA at time of biopsy was 6 (up from 4.1 of previous year). Biopsy took 16 cores, 12 of which had various amounts of cancer. 10 cores were 3-3 and 2 were 3-4. (Unfavorable intermediate, given over 50% cores having cancer.) My urologist sent cores our for Polaris test (genetic test) to assess level of aggression. I have an enlarged prostate (91 cc). My Urologist, who surgically removes prostates, advised against surgery and I will be seeing a Radiation Oncologist in his practice soon. Apparently, the practice has used Cyberknife for awhile. While I have heard and read good things about Cyberknife, I will likely be talking with other providers and other radiation or ultrasound treatments about a fuller range of options.. While I am 78, I am quite active (regularly work outside with chain saw and other power tools to clear brush and produce firewood from logs, lift weights and use the treadmill frequently.) Increasing longevity will be important as will continence and erectile function. Any further observations would be most appreciated.

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11 yıl önce radikal prostatektomi ameliyatı oldum. 1 ay önce nuksetti.
İktidarsızlık ve idrar kacirma var.
Şimdiki aklım olsaydı ameliyat olmaz radyo terapi alırdım.
Umarım sizin için her şey iyi olur.

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@mac44

Thank you for your information on cyber knife outcomes and your questions. My PSA at time of biopsy was 6 (up from 4.1 of previous year). Biopsy took 16 cores, 12 of which had various amounts of cancer. 10 cores were 3-3 and 2 were 3-4. (Unfavorable intermediate, given over 50% cores having cancer.) My urologist sent cores our for Polaris test (genetic test) to assess level of aggression. I have an enlarged prostate (91 cc). My Urologist, who surgically removes prostates, advised against surgery and I will be seeing a Radiation Oncologist in his practice soon. Apparently, the practice has used Cyberknife for awhile. While I have heard and read good things about Cyberknife, I will likely be talking with other providers and other radiation or ultrasound treatments about a fuller range of options.. While I am 78, I am quite active (regularly work outside with chain saw and other power tools to clear brush and produce firewood from logs, lift weights and use the treadmill frequently.) Increasing longevity will be important as will continence and erectile function. Any further observations would be most appreciated.

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He had radical prostatectomy 11 years ago. it had a relapse 1 month ago.
İ have impotence and incontinence.
If I had my mind now, I would have radiotherapy instead of surgery.
I hope everything goes well for you.

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@mac44

Thank you for your information on cyber knife outcomes and your questions. My PSA at time of biopsy was 6 (up from 4.1 of previous year). Biopsy took 16 cores, 12 of which had various amounts of cancer. 10 cores were 3-3 and 2 were 3-4. (Unfavorable intermediate, given over 50% cores having cancer.) My urologist sent cores our for Polaris test (genetic test) to assess level of aggression. I have an enlarged prostate (91 cc). My Urologist, who surgically removes prostates, advised against surgery and I will be seeing a Radiation Oncologist in his practice soon. Apparently, the practice has used Cyberknife for awhile. While I have heard and read good things about Cyberknife, I will likely be talking with other providers and other radiation or ultrasound treatments about a fuller range of options.. While I am 78, I am quite active (regularly work outside with chain saw and other power tools to clear brush and produce firewood from logs, lift weights and use the treadmill frequently.) Increasing longevity will be important as will continence and erectile function. Any further observations would be most appreciated.

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Your cancer does sound pretty treatable with radiation. There are other options though MRIDian radiation has a more focused team and damages less tissue around the area being treated.

Other non-radiation treatments are Focal Therapy, NanoKnife, cryotherapy, HIFU,, TULSA-PRO. I don’t know if you would have a problem because of your age, but it sure doesn’t seem like it, considering how a good shape you are in.

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@mac44

Thank you for your information on cyber knife outcomes and your questions. My PSA at time of biopsy was 6 (up from 4.1 of previous year). Biopsy took 16 cores, 12 of which had various amounts of cancer. 10 cores were 3-3 and 2 were 3-4. (Unfavorable intermediate, given over 50% cores having cancer.) My urologist sent cores our for Polaris test (genetic test) to assess level of aggression. I have an enlarged prostate (91 cc). My Urologist, who surgically removes prostates, advised against surgery and I will be seeing a Radiation Oncologist in his practice soon. Apparently, the practice has used Cyberknife for awhile. While I have heard and read good things about Cyberknife, I will likely be talking with other providers and other radiation or ultrasound treatments about a fuller range of options.. While I am 78, I am quite active (regularly work outside with chain saw and other power tools to clear brush and produce firewood from logs, lift weights and use the treadmill frequently.) Increasing longevity will be important as will continence and erectile function. Any further observations would be most appreciated.

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Thumbs up to your surgeon; so many don’t do right by their older patients and subject them to unnecessary surgery when radiation has the same outcomes and far, far less side effects.

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You clearly have reason for concern. Did you get a PIRAD rating on the lesions? The standard of care way of determining if you have prostate cancer is to biopsy the region of interest. You'll want to make sure it is an MRI fusion biopsy so that you have the best technology available to target and sample the region of interest. If you can have the biopsy done as transperineal, you'll have the lowest risk of infection. If not transrectal biopsy has some risk of infection, but it's reasonably low as I understand it. I had a transrectal biopsy. It's not a big deal. A biopsy is required in order to accurately assess if you have prostate cancer and it's staging. There is also a PSE test available which is a blood based test that can tell you with accuracies in the 90 percent range if you have prostate cancer. You might look into this test as a precursor to having a biopsy. Right now, you need more information and you need to get yourself educated. I recommend you spend some time looking at the many excellent videos available via the Prostate Cancer Research Institute, http://www.pcri.org. I consider them an excellent source of knowledge for the lay person.

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A PET scan should be the next step in validating cancer. MRIs are not perfect, and reading the cell configuration is subjective. A PET scan is more definitive. Do all the research you can on options if in fact, you have cancer. Keep in mind, one in seven men will have prostate cancer in their lifetime.

I undertook proton radiation therapy far back in 2010. A very good decision having researched at that time the options. I was in Spain, so little resources to research except the net. I went to Loma Linda Hospital in Loma Linda, California at that time one of few who had proton radiation therapy. Currently, there are many more institutions who now have proton radiation as an option. Good luck/RH=Florida

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@stew80. I'm 85 . Have you educated yourself oon Prostate Cancer . If not ASAP buy Dr. Patrick Walsh's book " Guide to Surviving Prostate Cancer " First : Your MRI should show your PI-RADS Score . It will be 1 ,2, 3, 4 or 5.
Pi-RADS 1 VERY LOW RISK -- NO SIGNS OF CANCER .
PI-RADS 2 LOW RISK - UNLIKELY TO HAVE CANCER .
PI-RADS 3 INTERMEDIATE RISK .
PI-RADS 4 HIGH RISK - LIKELY TO HAVE CANCER .
PI-RADS 5 VERY HIGH RISK . MOST LIKELY HAVE CANCER .
If you are RADS 1 or 2 Your Urologist may not send you for a Biopsy . He may suggest doing nothing , If you have 3 or higher . He should send you for a Biopsy There are different types of Biopsies . The best is a Transperineal MRI Fusion Biopsy . The older Transrectal Biopsy has a higher risk of infection -- possibly Sepsis .
After a Biopsy you will get the number os cores which may have cancer . It will assign a GLEASON SCORE . Google what Prostate Gleason scores mean .
Dr. Walsh's book explains all this and much , much more . A MUST BUY FOR SOMEONNE JUST DIAGNOSED WITH CANCER AND DOES NOT KNOW WHAT TO DO .
Don't panic - you will not die tomorrow . you likely had cancer for years and did'nt know .
NOTE : YOU CANNOT TELL FROM A PSA TEST , DIGITAL RECTUM EXAM ( DRE ) OR AN MRI THAT YOU HAVE CANCER . These tests only indicate suspicions . ONLY A BIOPSY CAN DETECT FOR SURE IF YOU HAVE CANCER AND HOW AGGRESSIVE IT IS . Depending on your Gleason score you may have to do nothing . They suggest Active Surveillance , like me , I have been on AS for over a year , many people are on AS foor years . This si also explained in Dr. Walsh's book .
Keep smiling -- you have years ahead .

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