Hey Jeff, I’ve heard about BRCA1/2 for years, and knew it mostly as it pertained to breast cancer in women. I had heard that it could also affect men, but until I met you on this forum I had never come across anyone who actually had the mutation.
It’s kind of like having 2 strikes against you already before you even get up to the plate.
I’ve been doing some reading on it in an attempt to grasp what it actually does in the body…my God!
What you say about it not allowing DNA to repair itself is just the tip of the iceberg. I got a headache trying to read the studies by the NIH and others; the biochemistry is on a level waaaaay above my station.
But it seems this collection of germ lines - as they are called - affect and are affected by insulin, fats and other compounds.
You are quite correct in cutting a lot of your sugar consumption because the mutation is insulin dependent in some people ( they still can’t figure out who/why) and the cancer rapidly progresses in the obese…..and worse, the mutation can affect the normal insulin itself, which then becomes a pathogenic form of insulin. It does similar things to lipids…
So the age-old question of the chicken and the egg becomes totally unanswerable; did the cancer cause X to happen…or did X cause the cancer?? In BRCA it seems the answer would be YES to both questions….ugh!!!