Hello @dbloom and @aisp3b I was talking to someone today who apparently has had a flare up of his PMR, (his wife is taking chemotherapy currently) He mentioned something about time zones -- he wishes he had tweaked the timing of taking his 10 mg Prednisone while in Oregon for 10 days ( vs. his home in RI) . SO I hope you'll manage very well on your trip to Switzerland ! Sounds wonderful !

The circadian nature of IL6 is mentioned in : PMRandIL6 website*.

"The effect of IL-6 on fatigue, mood,
and sleep was a result of its ability to stimulate the
hypothalamic-pituitary-adrenal (HPA) axis.43 In a study
of patients with PMR, IL-6 levels demonstrated a
circadian rhythm that peaked in the early hours of the
morning and correlated with the duration of morning
stiffness. "
* wow , which BTW seems to have much more info since I first stumbled upon it 1.5 yrs ago.