Just finishing up 4 months on Orgovyx. Never had a hot flash. Have lost weight, if anything. Very pronounced weakness and loss of strength about a couple weeks in. Joint and muscle pain almost from the start. Restless leg syndrome disappeared about a month in. Lessening of libido almost from the start. With effort and concentration, have managed one orgasm each month that I have been on Orgovyx. Took tadalifil to help night-time urination. Didn't help urination but no other deleterious effects that I could sense. It seems that Orgovyx has caused some stomach cramping and discomfort. Plus, I think it has definitely made my urination more urgent and frequent. Some of the painful twinges in the joints and muscles have been severe but only last 2-3 seconds. However, they made me feel that my joints were at risk of fracture. Until recently, I was an active 73 year old. Orgovyx has made me feel 100 years old. I hope I can rebound. I hope the ADT will prove to be worth it (not sure how I would ever really know...). Think I should have had the gene-based prognosis tools, decipher score, etc. As so many others have said, "Make informed decisions and don't second guess them." Best of luck to you! Stay strong.