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Prescribed Tymlos after Evenity

Osteoporosis & Bone Health | Last Active: Feb 25 2:33pm | Replies (99)

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@laujodrik

The reason they want me off Prolia is I started to have jaw issues. My dentist thought it was osseonnecrosis which is a serious jaw disease, and a rare side effect of Prolia. The MRI and blood tests were negative. I’m still having problems with my mouth/jaw and I have concerns about going on that type of drug. Tymlos/Forteo is my only choice, unless I want to believe the test results. It’s given me a lot of anxiety. Unfortunately, my dentist had a death in his family and won’t be back for a while. My appointment with my Rheumatologist is on February 25 and a decision has to be made by then. I’d love to go on Evenity, it is the same class as Prolia though stronger. I’m not sure what the answer is for me.

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Replies to "The reason they want me off Prolia is I started to have jaw issues. My dentist..."

@laujodrik not sure what you mean when you write that Evenity is in the same class as Prolia. Prolia is a very strong anti-resorptive and works by inhibiting RANKL. Evenity is both anabolic and anti-resorptive (the only drug that is both) and inhibits sclerostin. Their mechanisms are very different. But Evenity does carry some risk for jaw issues, though less so than Prolia and bisphosphonates.