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Looking for input on 2nd opinion after 3 years of Alendronate
Osteoporosis & Bone Health | Last Active: Jan 31 12:13pm | Replies (29)Comment receiving replies
Teriparatide (T) results in prolonged (longer) signaling of the cAMP pathway while Abaloparatide (A) is transient (shorter). The research paper linked below explains that this is related to how each bind to the parathyroid hormone type 1 receptor which has two conformations (R0 and RG). T has a greater affinity to the R0 conformation which results in prolonged signaling while A has a greater affinity to the RG conformation which results in shorter signaling.
The paper also explains that this accounts for the lower risk of hypercalcemia and less bone resorption signaling seen with A.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9586930/
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@oopsiedaisy thanks. I have read that study a couple of times, and it was posted very recently by @gently. It still doesn't answer my question about comparing dosing. The two meds are different in some ways yet posts tend to say that Forteo is lower dose. I am going to ask my doctor if dosage comparisons are apples to apples or apples to orange!