Hi, I was on cymbalta two different times and it generally helped me a lot. I transitioned to another med the first time due to insurance issues for a while and then went back on it. I don't remember any problems taperi g off of it to another drug.

I have to say though, that the second time i was on it, I did develop a manic episode that built after a few months of hypomania after I had been on it for about 6 months. I also received steroid shots during this time for Rheumatoid arthritis and was under extreme stress at work and home. Most notably, i did not talk to my psychiatrist about being hypomanic until it was too late apparently. For months i didn't need to sleep much and was highly productive. But then it tipped to mania and I couldn't sleep. That was my first manic episode, and I was 61! It took a few months to "come down." And then I really crashed into my worst depression ever.

I don't know how much each element contributed to the manic episode: cymbalta (it's a risk factor), steroids (another risk factor), and the extreme stress. My pdoc said she believes I was misdiagnosed with Major Depression when I actually had bipolar type 2. There is a lot in the lit about antidepressants triggering type 1 mania in type 2 patients.

I was put on many different meds, allergic to some(lamitrogene, lithium, depakoate), not responsive to others, and not covered when I lost my job and went on Medicaid. I have finally settled on Prozac (80) and seroquel (200 mg) for a couple of years and seem ok. I think i could be better. I did the dna test for medications this week and look forward to learning if something will work better. I don't recall having any physical withdrawal problems with going on and off all those meds. I DID have a bad reaction to seroquel at the 800 mg they prescribed. Horrible anxiety, nightmares, panic attacks. I reduced the dose immediately with my doc's ok.

So all of this is just a cautionary tale about the risks of any meds. And to be proactive with self observation, ensuring adequate sleep and relief if other symptoms arise. I know I waited too long to get help.

Be brave. Some of us NEED treatment all our life and we have to find out what works best. Only trial and error. Best wishes on your journey!
Cathy