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If you have tapering problems below 5 mg this might explain why.

Polymyalgia Rheumatica (PMR) | Last Active: 54 minutes ago | Replies (62)
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@rosemargaret

I have had PMR for 7 years and have been at 3mg. daily to get off Prednisone for 2 years. At the beginning of October I was put on Methotrexate to help wean off the Prednisone. A couple of weeks ago I started getting some chest pressure and random light chest pain. (I do have Hypertrophic obstructed cardiomyopathy but have not had any pain). Could the Methotrexate have triggered the onset of chest discomfort?

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Replies to "I have had PMR for 7 years and have been at 3mg. daily to get off..."
prestol | @prestol | 5 days ago

I think you really need to report this to your cardiologist. MTX has many potential side effects, some serious. Good luck.

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art43 | @art43 | 4 days ago

@rosemargaret
Chest pain/tightness with a known cardiac issue = go to the ER. It might save your life.
Opinions here, or personal speculation about the possibility of methotrexate causing your discomfort are not presently relevant.
Ask me how I know. Good luck.

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