← Return to Looking for input on 2nd opinion after 3 years of Alendronate

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@gently

patwerthman, I'm curious about the source of your virtual recommendation.
I don't have experience with the medications except Forteo. Bisphosphonates are now recommended for three to five years. Because you haven't gained density with alendronate over the last year, it's a great time for the switch. I have a preference for Forteo because it is a lower dose of medication than Tymlos and because I'm not content with the mechanism of action of Evenity.
There isn't a way of determining how much bone loss aledronate has prevented. You probably have and will maintain fracture protection for several years from taking it, even as your bmd remains low.
In your situation, I would take Forteo or Tymlos for two years. Prior bisphosphonate use is said to delay the effectiveness of either medication, studies have shown that there isn't significant difference after one and two years of use. There isn't actual rebound with either Tymlos or Forteo. There is gradual bone loss after you quit using either drug.
I'm starting a third year with Forteo. At 16 months the T score changes in the spine were from -3.3 to -2.8; femoral neck -3.0 to -2.9 ; right hip loss from -2.4 to -2.5. The trabecular structure improved reducing fracture risk in the spine and the hips.
The endocrinology response surprises me.

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Replies to "patwerthman, I'm curious about the source of your virtual recommendation. I don't have experience with the..."

I did a paid virtual second opinion with Cleveland clinic. They interviewed me and gathered my medical past with test results & clinic visits. Sent a report with recommendations

@gently I didn't realize you could use Forteo past two years. Also thought its effectiveness waned the longer you use it. You say you are starting a 3rd year; if you know of a study documenting results at that point (or further along), could you let me know?