I have had a one point increase and they said it was nothing to be concerned. My ca125 usually ranges in the 12-14 range. I get tested every three weeks with my zirabev infusion. I’m 11 months out from end of frontline chemo. I have to tell you I was freaked about a one or two point increase as well but it did come back down on the next one. I read some article about not to worry unless over a five point increase but truly I think you can find just about anything you want to hear on the internet. Hope this helps.