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New peripheral neuropathy drug gets FDA advance
Neuropathy | Last Active: 3 days ago | Replies (15)Comment receiving replies
I have the same, numbness, poor balance and zero pain. I've been curious for years about two things. First, why do some people suffer from pain and others do not? Second, why does PN affect most people in their mid to late 50's, and mainly 60's and 70's. With idiopathic PN, is age a trigger but the cause is from something years prior to be diagnosed with PN. I agree with you at this point, a cure is doubtful but perhaps not impossible.... someday.
Replies to "I have the same, numbness, poor balance and zero pain. I've been curious for years about..."
There are recent data indicating that , in the case of diabetic related peripheral neuropathy, blood glucose "time-in-range" correlates with the severity of PN and the presence or absence of pain. Hence the value of continuous glucose monitoring, as opposed to HbA1c monitoring. The more you can stay in the "safe" glucose range on a daily basis the better your prognosis may be. For most diabetics, the damage is already quite severe and very difficult to reverse by the time they are diagnosed. And, in my opinion, HbA1c is often the culprit, giving a false sense of security, sometimes for years while damage is accumulating. The paper linked below seems to agree with me on this issue . You can now get FDA cleared over-the-counter continuous glucose monitors at a reasonable price and with a reasonable level of accuracy.
https://pubmed.ncbi.nlm.nih.gov/35394566/
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Ed I've had those same thoughts for many years. The pain I have is not neuropathy but is more old age and degenerative arthritis. I think part of the answer on the neuropathy end is the cause not being known. If you have lots of time and like digging into stuff, the metabolic syndrome and it's connection with neuropathy is kind of interesting. I think it also explains a lot about being told your pre-diabetic and nothing is mentioned by your doctors about the metabolic syndrome.