I have had 4 injections of Inclisiran so almost 2 years. The 2nd injection is 3 months following the first, then 6 months apart after that. I imagine it works on its own, maybe not quite as well? The information we read is based on the studies they’ve done, and I don’t think it’s been studied by itself. A good doc should know the answer to this question. As far as side effects, I have learned that some are actually things patients reported but may be part of the body adjusting to the drug in an expected, good way. If you think about it, every drug you take goes through your entire body. If you do something to make the body change how it works, it does just that. It works differently. I was told 10 years ago (at Mayo) when I was on this path of trying cholesterol drugs…there are 3 possible outcomes: net positive, net neutral, net negative. Certainly we want to avoid negative where the impact to the body is worse than the good the drug will do. To me, the other two is where “the art of medicine” comes in.

I can only tell you what I have done, what has worked for me and what has not. It truly does all come down to deciding what you want to accomplish. My cholesterol is better today than it ever has been. I am feeling better and better. I am taking drugs that have previously caused me problems. So, was this the drug, my body, or how the drug was being used? It has come about through an intentional process of figuring “me” out and digging beyond a simple LDL marker. What I do know is that I am not a trained doctor and I do not understand the drugs. I’m not sure all doctors can. Step #1 is to have a doctor you trust, then #2 help you pin down what your risk is. Once you can sorta quantify your risk you will know what you are trying to accomplish. Do you need Repatha or a statin?

I am focused to stay on a path I know is a net positive. This creates a lot of noise around me by other people, consequently a different type of stress. It is completely isolating at times when their bias takes over. This gets off our topic of statins but I truly believe you have to figure out what you want and that will help you figure out the rest. You have done such a good job of managing all this. Is your piece missing to find a medical person to tie it all together (or untie it?) Maybe you have recommendations for me.