I am also on the trial, cycle 10! My cohort is 1200mg RM 9805-KRAS G12D (the max dose) and as of this cycle, 200 mg RM 6236 (pan KRAS). Skin nuisances, mostly on my face but also randomly on fingers. Basically, it really dries your scalp so some little sores appeared there. The face is more irritating, because it creates tiny white blisters. Doxycline doesn't help me much, but I do try to use the gel twice/day. It dries everything up which creates more issues. So I use Vitamin C/E oil and some serums. Basically, a little nausea for about 30 min after taking it then life as normal. The side effects are FAR different than the chemos we all know.

I am in phase 1b which has select dosing requirements different than the other cohorts. RM6236 is getting tons of attention and it looks to be moving rapidly into phase 3. Some sites are administering it to first line patients with Gem/Abraxane.

Revolution Medicine will be of very little help, if at all. Call the sites listed as hosting their trials for details about which cohort they may be registering. Feel free to reach out to me, also, if I can answer any questions. I am in trial at Carolina BioOncology in NC.