@mgabby17, I was diagnosed with PSC probably around the year 2000. I also took URSO. I gradually developed fatigue and was prerty much symptom free until summer 2008 when my itching began. Gradually the itch got worse and I was miserable. I tried topical creams and for me I got some relief fron Sarna anti itch lotion. I also found some relief by taking a warm soaking bath in Aveeno Oatmeal Bath Treatment. My GI prescribed, Cholestyramine (Cholestyramine - used to treat itching caused by a blockage in the bile ducts of the gallbladder). That did offer some relief. I don't remember how long I took that because my liver began to decline and I developed other symptoms, and was referred for a transplant in late 2008. I received a transppant in April 2009.

@mgabby17 - I want to share the link to PSC Partners Seeking a Cure. They provide education and support to people directly affected by PSC.
https://pscpartners.org/
- Mgabby17, Are you having any other symptoms with your PSC? Are you being treated by a GI with liver experience or a liver specialist?