I was switched from Effexor to Trintellix. I wish I never took Effexor, the side effects of coming off of them are horrible. I feel "brain zaps", feel like I could "snap" and it feels like things are lagging if that makes sense. I have been crying, feeling mentally off. I wish doctors would tell their patients about the withdrawals from this drug. It's awful and I am wondering how long I have to deal with this. It's making me more depressed. My hopes is that Trintellix will help my depression, I already know that it does not have the horrible withdrawal effects if I ever have to go off of it. (I was on Effexor 75mg daily) Thanks for letting me share my experience. I was told that fish oil, frozen and taken at night will help minimize the side effects, so I will try that.