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Strontium citrate (Algaecal) and fractures

Osteoporosis & Bone Health | Last Active: Jan 23 11:05am | Replies (137)

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@oopsiedaisy

Thanks for the additional info. I fractured 13 months ago and have not fractured since so I hope I am on the right path now. I stopped Fosamax 11 months ago, was off all meds for 3 months, then did 4 months of Tymlos followed by two months off and now on teriparatide.

Knowing what I know now, I would never have taken Fosamax for as long as I did.

That is very interesting info regarding the "sacrificial bonds". Looking forward to diving into the info after work today.

I was on the Inspire forum shortly after my fracture was diagnosed but dropped it when I was told (in very bold and insistent terms) that Tymlos would give me cancer.

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Replies to "Thanks for the additional info. I fractured 13 months ago and have not fractured since so..."

Yes, there were some studies with rats that showed a risk of bone cancer. I have not seen any research to back this up with humans. But the warning was on the Tymlos site, at least at one time.
https://tymlos.com/
Research:
" the initial phase 3 trials of the bone anabolic drug teriparatide were stopped because of a preclinical finding of osteosarcoma in rats treated with high doses of teriparatide for near lifetime. Even so, teriparatide was observed to reduce fracture risk in postmenopausal women with osteoporosis and showed efficacy and tolerability in the phase 3 program and in subsequent studies with a positive benefit to risk profile. Based on the phase 3 results, additional preclinical findings, and with risk mitigations, the agent was approved for use. Subsequent studies including in real‐world settings have not identified an increased risk of osteosarcoma in humans, and the label has been updated and adjusted, including removal of the boxed warning and a revision of the 2‐year lifetime limitation. Thus, observational studies with large sample sizes using real‐world data can be an important and efficient strategy for generating evidence in support of regulatory decision making and significant label updates."
https://pmc.ncbi.nlm.nih.gov/articles/PMC9465003/