I started Repatha a year ago. I had little side effects at first. I have been taking simvastatin also. I found that this is the only statin that I can tolerate in a low dose. I take 10 mg day 1, then 10 mg the next day and 20 on the 3rd day, otherwise I start getting the muscle aches. At first I had few side effect with repatha. I only take it once a month. Lately though the side effects have been getting worse. Leg pain, knee pain, back pain, flu like symptoms, my head hurts, sometimes my stomach aches. I am an avid cyclist. I cannot live like this. I had a heart attack in a minor blood vessel about 2 years ago. I was having some mild pain riding up steep hills, but then I rode with some faster people and the pain grew more intense. I went to the emergency room and sure enough. They tried to open the blockage but they couldn’t and then wanted to go in again with heavier duty equipment to try to clear the blockage but I declined it for fear that something might go wrong. They gave me a beta blocker which actually prevented my heart rate from entering the pain zone (greater than 120). I was back on the bike in 2 days. Gradually I stopped taking the beta blocker and I no longer have any pain. It is logical that collateral blood vessels developed around the blockage which solved that problem. Back to the Repatha. I will skip taking it all together next month and try again the month after. I am very sensitive to most medicines. After all, you have to realize that these are really poisons we are putting in our bodies. It does seem, at least for sensitive individuals, that the side effects build up over time with Repatha. It takes up to 85 to 102 days to leave you system completely. This tells me that if you take it twice a month or once a month there is a certain amount (remnants) that will be accumulating in your system, like it or not. My body is telling me that it doesn’t like it.