Clay colored bowels & diarrhea side effects with Octreotide

I have been on Lanreotide 120mg since April 2023. First few injections were with bad reaction (nausea, vomiting), I take Zofran 10-15 min before the shot. Light colored stools and diarhea are result of Steatorhea and maladsorption, due to lack of pancreatic enzymes. I have been taking Creon and it seems to help.
I had distal pancreatectomy, removal of spleen and gallbladder(which gets damaged from the drugs, so they remove it) and debulking liver surgery to remove larger metastatic tumors.
Reach out if I can be of any help!
Believe me - it gets better!!💜🦓

You are welcome. My blood work up, which they do every month, shows liver and kidney function are fine. However, tumor in liver is growing, so now moving to TARE (Trans Arterial Radio Embolization).

We sound very similar. Small bowel primary with mets to liver. Started octreotide after bowel resection. I had the same side effects. I stopped the monthly injections after 1 year because the diarrhea was not being managed well enough with Imodium. My tumors shrunk but I recently found out they have grown and there are new ones. I'm headed to a consult for PRRT today. Not looking forward to that treatment. I should have just suffered thru the diarrhea. I wish you well on this journey.

Thanks for your reply. Dr Liu of Rocky Mountain Cancer Center has a facebook page, Dr. Liu's Zebras: A Neuroendocrine Cancer Community. https://www.facebook.com/groups/402282629858283 It is a private group. Submit your info to join, He does a zoom call once a month I believe. I listened to the one last night which is recorded and posted on the site as is the one for last month. All of the prior monthly meetings are posted under media and then select video. He mentioned PRRT. He said it was sometimes good but not always. Could affect bone marrow and blood sugar. He does telemedicine visits and I know several people who did see him that way and were pleased to get his opinion on a course of treatment. What was the length of time from when you stopped the shots till you saw that the tumors had grown and there were new ones? Best of luck with your appointment as you pursue a treatment that is right for you. Do let me know what you decide and how you are doing with the new treatment. Joy
Dr Liu office can be reached (303)388-4876
Carina.Carnelian@usoncology.com

My experience is that it’s hard to say if my diarrhea is from the cancer, the meds or diet. So could it be any combination ? Hard to say, but the meds certainly are something I feel great about taking. Just knowing there is something that we can use to battle the cancer. Creon and Xermelo are two meds besides monthly Landreotide injections that are part of my plan. You may want to ask your doctor about them.