I have been using medical-grade Indica edibles for relief from the pain and symptoms of motor and sensory neuropathies for the last ten years or so. It is the only thing that provides relief and allows for restful sleep. I need to take it a couple of hours before I go to bed; otherwise, I can be groggy in the morning. Finding the strain and products that work for me took a while. I haven't experienced any side effects, at least nothing like the side effects from drugs like Cymbalta, gabapentin, or Lyrica. The biggest challenge is not building tolerance. I would love to use it each evening but only take it every third night to avoid building tolerance. When you build tolerance, you must consume more and more for the same effects. Some people avoid tolerance by alternating between Sativa, Indica, smoking, vaping, and edibles. Sativa does not work for me, and Indica edibles are the only thing that provides deep body relief. Then there is the cannabinoid/terpene relationship, but I rely on an herbalist friend who owns a dispensary to do the scientific work for me.