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Anyone had CAR-T therapy for solid tumors? (pancreatic cancer)

Bone Marrow Transplant (BMT) & CAR-T Cell Therapy | Last Active: 17 hours ago | Replies (20)
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@kirkwilliams2049

I am in Edmonton Alberta Canada so this is probably not applicable depending on where you are located. My understanding is that modified T cells look for the CD19 marker on offending/mutated B cells. Both variations (Standard of Care and locally modified) look for this marker. Bear in mind that I am a patient not an expert.

There was a study done about 2.5 years ago that indicated that if your B cells are histiocyte rich, that CAR-T had no effect. The study group was only 9 patients so it is far from a statistically significant group. I can’t locate the study right off but it was reported by the National Institute of Health. Again I am not an expert but this may give you some talking points to discuss with your team.

Hope things work out for you. I am pleased to answer any other questions you may have.

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Replies to "I am in Edmonton Alberta Canada so this is probably not applicable depending on where you..."
val64 | @val64 | Jan 20 3:53pm

CD19 is a protein that is found exclusively on the surface of B-lymphocytes (aka B-cells) and B-cell malignancies. It is the target of the CAR-Ts used to treat B-cell malignancies.

The goal in designing CAR-Ts is to identify a protein found only on the surface of certain cancer cells, but no normal cells, and have the CAR-T target that. For B-cell malignancies that is CD19. For other cancer types it is different proteins. The CAR-T for treating a pancreatic cancer would target a different protein.

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