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Lupron: Anyone have muscle weakness and severe leg pain?

Prostate Cancer | Last Active: Feb 5 4:43pm | Replies (65)
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@alrunner

I was a pretty good marathon with decent speed running 30-40 miles a week. Received a Lupron injection 6 months ago and completed Proton radiation 4 months ago. PSA is was tested 2 days ago and is undetectable. For past 2 months I have been dealing with leg pain during runs staring in mile 2 or so. Legs feel like mile 30 of a marathon with so much discomfort I only managed 4 slow painful miles today. Doctors don’t give me a definitive answer.

I know I am lucky to be out there but can anyone tell me of similar experience and if you ever got past the leg pain. This only happens when I run.

Of course I have other side effects like hot flashes.

Thank you
Al runner

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Replies to "I was a pretty good marathon with decent speed running 30-40 miles a week. Received a..."
Colleen Young, Connect Director | @colleenyoung | Jan 31 9:08pm

@alrunner, it must be so hard to struggle through 4 miles when you're accustomed to running marathons and training. I'm tagging a few of the fellows here like @thehowlingdog @ssonkin @jerryegge @rice @seasuite who are also runners and are living with prostate cancer treatment.

Just to clarify, you only experience the leg pain when running, correct? How about when you do other activities like strength training or stretching?

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shimutale | @shimutale | Feb 4 3:51am

How are your hot flashes like? Mine have been hectic coupled with serious sweating at almost hourly intervals. I live in Zambia, Southern Africa and Livingstone in particular which is one of the hottest places in the country. I was commenced on Luprodex injection and Bicalutimide 50mg tablets in March 2023 (every 3 months). The 2nd one was in July 2024 and had the last one in October 2024 before under going Prostatectomy on 5th November 2024. Three months down the line, still experiencing serious hot flashes and sweating. Wonder when these side effects will go down

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graybeard46 | @graybeard46 | Feb 5 11:44am

I have been getting cramps in my thighs almost every day night 🤷‍♂️

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