@rashida I am not using RANKL as an acronym but I see it is one! I have only seen it as RANKL 🙂
https://en.wikipedia.org/wiki/RANKL

rashida, too many acronyms. RANK is a T-cell part-- of our immune system. The ligand part makes it a pathway. This pathway stimulates the formation and activation of osteoclasts.
It is really so interesting all the pathways the chemical dominos that fall in the development of our bones. I like this video even though they shouldn't make the osteoclasts so ugly. Both Prolia and the bisphosphonates block the RANKL pathway. https://www.youtube.com/watch?v=aenbmrXUH0U