That is exactly why I am trying to get off of effexor. The "horrible" constipation got so bad that I ended up in the ER. (Trust me, it is less painful to give birth than to go through that). I use miralax too, but I let it slide this time thinking my increase in fiber and veges would take care of the problem naturally. I was mistaken. Also the dry mouth has been horrendous. I've been sucking on cough drops every day for 2 years to get some relief. I recently discovered Biotene mouth rinse which helps. I am on day 6 of my dosage reduction and have been removing a few pellets from the capsules each day. I expect to be able to get down from 150 mg to 112.5 mg by Saturday.