@serious I have atrial fibrillation with heart rate up to 200, sporadically. The entire two years on Tymlos I didn't have a single episode, which was unexpected but welcome.

I do not have personal experience as mentioned above but from my doctor, books, videos and fellow posters (including @mayblin) I think a summary would be, that Prolia is a good choice if:

1) you can't take anything else
2) you do 1-3 shots then Reclast
3) you do 1-3 shots after Evenity (for a boost) then Reclast
4) you can do 10 years (or more as studies progress) if you are old enough to think you won't have to stop.

As with all drugs, some people have side effects, but the main concern is the dramatic rebound loss of bone density and increase in fracture risk. Also know that it may affect future effectiveness of Forteo, Tymlos or Evenity.

My doctor jokes that he will prescribe Prolia when he is retiring so he doesn't have to deal with rebound. That said, it is pretty effective at boosting bone density as an anti-resorptive.

ps I have had cancer, and have lupus and high antibodies for scleroderma so Prolia is concerning for me, personally, due to the fact that it works with RANKL and may affect the immune system.