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Bone turnover markers (CTX and P1NP): do you have a baseline?

Osteoporosis & Bone Health | Last Active: 3 hours ago | Replies (197)
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@gently

hi mayblin, if it were repeatable would repeats obviate the significance of stage?
Many of the research articles use CTX and P1NP as direct indications that bones are strenghtening or at least gaining density. Is there a CTX/P1NP thread? It would be interesting to align bone markers with dxa results.

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Replies to "hi mayblin, if it were repeatable would repeats obviate the significance of stage? Many of the..."
mayblin | @mayblin | 3 hours ago

That's a great question @gently . I'm amazed with the fact that the original 2yr treatment limit for Forteo coincides with the anabolic window, which was reflected in CTX and P1NP changes in various studies. If the results of Fisher rats didn't exist, we'd have a lot more info about teriparatide's longer term efficacy, maybe a lot more about dosing regimen as well. Moreover, we might not have the current situation where long term op management is heavily dependent on antiresorptives while the other side of equation is partially missing.

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