I'm not sure what you mean about "supplement regimen"? I went from 150 mg to 75mg then down to 37.5. Week by week by week. I think the decrease was too fast. I have taken it for such a long time, my body needed more time to "detox" from each decrease. These drugs are nothing to take lightly, let me tell you. The side affects and anxiety will just about kill you....tread lightly and ask your doctor LOTS of questions and don't hesitate to question their suggestions. You know your body best....good luck.