Hi @ninglike i read a the study regarding optimal injection time but that was so small that we should look at the results with a grain of salt. If true, MDs or pharmacists would have advised patients to do one way or the other. In reality there appears to be no concensus. My take is at the beginning you inject at a time that is best for you to minimized unwanted side effects, since each person reacts to a new medication differently. Once your body is customed to Forteo, you could transition to the time that you believe is the best for bone building. If you come across a good reliable clinical study, please share.