Recently had my gallbladder removed after acute episodes of severe discomfort and a lab report that liver was being affected. Nothing showed up on various scans, x-rays, etc.
Doctor said it was very enlarged, and difficult to remove through laparoscopic incisions. Evidently a duct was twisted.
And, I felt so much better immediately. Realized it had been making me ill for over a year. Thought it was from other conditions.