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Prolia discontinuation

Osteoporosis & Bone Health | Last Active: 5 hours ago | Replies (32)

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@yellowbrd

This is my first comment ever. But here goes..I am 78 and had my first Prolia injection on 12/23/24. At my 2 week follow up visit I mentioned to NP that I was suffering from constipation and stomach pain. She said "its not because of Prolia". I thought it would get better, but upper stomach pain is bad all day and night. Today NP told me to see my Primary Dr or go to Urgent Care. She insisted Prolia was no longer in my system. I am getting really worried about getting another injection in June. Any thoughts about stopping the program before it's too late? Thank you in advance for any advice or thoughts. I have read the posts and it is so easy to get overwhelmed.

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Replies to "This is my first comment ever. But here goes..I am 78 and had my first Prolia..."

This is from webMD.com

"How Long Does It Stay in Your System?
Prolia takes about 4 to 5 months to leave your system.

If you could become pregnant while on Prolia, you must use birth control during treatment and for 5 months after the last dose of Prolia. "

hi yellowbird, anyone experiencing the said to be "rare" experience of constipation with Prolia is advised to contact their physician immeditely. Prolia stays in your system 4 to 5 months. Half life is 26 days.
Did the NP prescribe the the Prolia? If there is an md involved, you might/should contact them. But you probably need a new provider.
I'd suggest a bisphosphonate to counteract any rebound from the one injection of Prolia. If you opt for Reclast make it a low dose, slow infusion. You have till June to figure all that. Meanwhile be sure to use measures such as milk of magnesia to alleviate the constipation.
And don't let this be your last comment; make it a conversation.