1. < Prostate Cancer

Prostate Biopsy Complication

Posted by handera @handera, Jan 9 3:24pm

Diagnosed in October 2023 with low volume Gleason 3+4, decipher 0.22. Post biopsy PSA’s have average 6.2, compared to 7.8 prebiopsy.

My 12 month mpMRI indicated only the largest of the original three (PIRADS 3, 4 & 5) lesions was visible and it had reduced T2 and DWI/ADC signaling so everything is looking good regarding the MRI and reduced PSA.

It took me more than 2 months to recover from my 1st biopsy (21 cores) and I’m not looking forward to getting another.

Actually, even after 15 months, I still experience a low level groin soreness where tissue scar may have formed, near a nerve, after the biopsy procedure. Nothing major, more of an annoyance and a minor aggravation.

I found out this is a recognized complication of prostate biopsies; especially for those having large numbers of cores taken.

Has anyone experienced this biopsy complication?

If so, how long did it last and did you find anything to alleviate it…or did it eventually just go away?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

clandeboye1 | @clandeboye1 | Jan 12 10:28am
In reply to @jc76 "@billfarm I was adamant about not having my biopsies done via transrectal. I was told increase..." + (show)
@jc76

@billfarm
I was adamant about not having my biopsies done via transrectal. I was told increase in infection was 1-2 % and if I did get infected would only have to spend 2-3 days in the hospital.

My urologist did not want to do transpernial but transrectal. He used the excuse of my HF. But I got my HF and EP to contact him and they did saying my HF would not be a problem with gettig anesthesia. The transpernial (at least at Mayo Jacksonville) is done in a surgery room with anesthesia and anesthesiologist.

It removed the stress and anxiety over the procedure. I had not discomfort before, during and after. It is funny isn't it when you hear a urologist say only 1-2% or only 1 in 750 die in biopsy when they are not the patient.

One poster was told was only 1% infection rate and say guess he was lucky as he became one of the 1% with a real hard time getting rid of the infection. To each his own though some have no issue with the increased infection rate, nor the procedure done without anesthesia, nor going through rectum, ect.

That is why we are all different and need to do what is best for us. I challenged my urologist for what I wanted and did not accept his. We have to be our own patient advocate. It is our bodys and our cancer.

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Excellent post . Be your own best advocate . Never take NO for an answer . You have heard of The Peter Principle . I work on The PITA principle . Pain-in-the-Ass principle .
I am so persistent , action is taken promptly to get rid of my annoyance .
Keep well.

REPLY
billfarm | @billfarm | Jan 12 8:45pm
In reply to @jc76 "@billfarm I was adamant about not having my biopsies done via transrectal. I was told increase..." + (show)
@jc76

@billfarm
I was adamant about not having my biopsies done via transrectal. I was told increase in infection was 1-2 % and if I did get infected would only have to spend 2-3 days in the hospital.

My urologist did not want to do transpernial but transrectal. He used the excuse of my HF. But I got my HF and EP to contact him and they did saying my HF would not be a problem with gettig anesthesia. The transpernial (at least at Mayo Jacksonville) is done in a surgery room with anesthesia and anesthesiologist.

It removed the stress and anxiety over the procedure. I had not discomfort before, during and after. It is funny isn't it when you hear a urologist say only 1-2% or only 1 in 750 die in biopsy when they are not the patient.

One poster was told was only 1% infection rate and say guess he was lucky as he became one of the 1% with a real hard time getting rid of the infection. To each his own though some have no issue with the increased infection rate, nor the procedure done without anesthesia, nor going through rectum, ect.

That is why we are all different and need to do what is best for us. I challenged my urologist for what I wanted and did not accept his. We have to be our own patient advocate. It is our bodys and our cancer.

Jump to this post

I suspect the urologist dead set on transrectal may not have had access to the the trans peritoneal equipment or was not trained on it and didn’t want to miss the revenue. A similar situation seems to exist in radiation. Radiologists that don’t have training in or access to proton equipment claim that photon is just as effective side effects be damned. Because they want the procedure for their clinic. You got it right that you are your own best advocate and you do have the last word. Be well!

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heavyphil | @heavyphil | Jan 13 6:23am

New EPICAPTURE TEST. A small Dublin based biotech co (TRIB?) announced that they have a new urine test that is almost 100% effective in diagnosing aggressive (Gleason 8 or higher) prostate cancer.
It is used along with PSA tests mostly in the gray area of 4-10. It shows methylated DNA in the urine which is associated with more aggressive cancers. It’s a good option in AS to avoid repeated biopsies.
There are other urine tests out there but supposedly this is the first one that takes into account other factors - and the test was matched up with an actual biopsies and showed a high rate of predictability.
This is great news and offers men another piece of data they can use to make a more informed decision about whether to re-biopsy or not.

REPLY
2 replies
clandeboye1 | @clandeboye1 | Jan 13 8:00am
In reply to @heavyphil "New EPICAPTURE TEST. A small Dublin based biotech co (TRIB?) announced that they have a new..." + (show)
@heavyphil

New EPICAPTURE TEST. A small Dublin based biotech co (TRIB?) announced that they have a new urine test that is almost 100% effective in diagnosing aggressive (Gleason 8 or higher) prostate cancer.
It is used along with PSA tests mostly in the gray area of 4-10. It shows methylated DNA in the urine which is associated with more aggressive cancers. It’s a good option in AS to avoid repeated biopsies.
There are other urine tests out there but supposedly this is the first one that takes into account other factors - and the test was matched up with an actual biopsies and showed a high rate of predictability.
This is great news and offers men another piece of data they can use to make a more informed decision about whether to re-biopsy or not.

Jump to this post

Where did you read this announcement article ?

REPLY
1 reply
handera | @handera | Jan 13 9:20am
In reply to @heavyphil "New EPICAPTURE TEST. A small Dublin based biotech co (TRIB?) announced that they have a new..." + (show)
@heavyphil

New EPICAPTURE TEST. A small Dublin based biotech co (TRIB?) announced that they have a new urine test that is almost 100% effective in diagnosing aggressive (Gleason 8 or higher) prostate cancer.
It is used along with PSA tests mostly in the gray area of 4-10. It shows methylated DNA in the urine which is associated with more aggressive cancers. It’s a good option in AS to avoid repeated biopsies.
There are other urine tests out there but supposedly this is the first one that takes into account other factors - and the test was matched up with an actual biopsies and showed a high rate of predictability.
This is great news and offers men another piece of data they can use to make a more informed decision about whether to re-biopsy or not.

Jump to this post

Thanks for this information! I've been researching various liquid biopsy alternatives for AS patients and I had not seen this one. Apparently, Trinity Biotech bought the start-up company who invented the Epicapture Test in October 2024 and has announced plans to commercialize in the US...however, no date has been set....

Read where this particular test only has 5% false positives....that's amazing when one considers that the false positives for the standard PSA blood test is 46.6%, according to a 2022 study….imagine if a company were attempting to bring such a test to market in 2025....that type of test wouldn't even make it to first base after an initial screening of possible solutions.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9818944/
In 2021, ~60% of low risk PCa men have chosen AS, as compared to only ~26% in 2014. This means that the market for a noninvasive biopsy method has grown exponentially; therefore, I believe it's just a matter of time (sooner rather than later) that such a liquid biopsy replacement test will be made available...there is a large and growing market and we all know what the means for the medical industry....

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1 reply
heavyphil | @heavyphil | Jan 13 9:41am
In reply to @clandeboye1 "Where did you read this announcement article ?" + (show)
@clandeboye1

Where did you read this announcement article ?

Jump to this post

It was actually a TV advertisement on a business show.
Google the name of the test and you’ll get numerous articles about it

REPLY
clandeboye1 | @clandeboye1 | 6 days ago

Thanks . Do you know if this test can be ordered in North America ( Canada / USA ) and be paid for privately ?

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2 replies
heavyphil | @heavyphil | 6 days ago
In reply to @clandeboye1 "Thanks . Do you know if this test can be ordered in North America ( Canada..." + (show)
@clandeboye1

Thanks . Do you know if this test can be ordered in North America ( Canada / USA ) and be paid for privately ?

Jump to this post

Not sure as it is very new

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1 reply
handera | @handera | 6 days ago
In reply to @clandeboye1 "Thanks . Do you know if this test can be ordered in North America ( Canada..." + (show)
@clandeboye1

Thanks . Do you know if this test can be ordered in North America ( Canada / USA ) and be paid for privately ?

Jump to this post

Apparently the EpiCapture test is undergoing regulatory approvals in the US (not sure about Canada); which could take as long as 1-2 years. A couple studies, involving ~450 men each, have been published.

From what I read, in order to "correctly predict all high grade cancers" the EpiCapture test results must be combined with a man's PSA level, via a proprietary algorithm.

Trinity Biotech (the company who bought the EpiCapture Test start-up company) showed some revenue growth and has improved their net operating loss in their most recent Q3 2024 financial report. Sounds promising, but still a ways to go.
https://www.stocktitan.net/news/TRIB/trinity-biotech-announces-q3-2024-financial-53coj4nfk6qn.html

REPLY
1 reply
clandeboye1 | @clandeboye1 | 5 days ago
In reply to @handera "Apparently the EpiCapture test is undergoing regulatory approvals in the US (not sure about Canada); which..." + (show)
@handera

Apparently the EpiCapture test is undergoing regulatory approvals in the US (not sure about Canada); which could take as long as 1-2 years. A couple studies, involving ~450 men each, have been published.

From what I read, in order to "correctly predict all high grade cancers" the EpiCapture test results must be combined with a man's PSA level, via a proprietary algorithm.

Trinity Biotech (the company who bought the EpiCapture Test start-up company) showed some revenue growth and has improved their net operating loss in their most recent Q3 2024 financial report. Sounds promising, but still a ways to go.
https://www.stocktitan.net/news/TRIB/trinity-biotech-announces-q3-2024-financial-53coj4nfk6qn.html

Jump to this post

Apparently a test invented at The University of Michigan, the MPS2 Test is similar . It is a urine test whichh also looks at your current PSA

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