Hi Bette, , your neuropathy is quite different from mine. yours is only in one leg and in no other part of the body? How long ago did this arise and was it associated with an injury? Do you have lower back issues?

Your isolated right leg pain may be due to a compressed lumbar disc, which I believe you made reference to in another message. You also mentioned more generalized, bilateral, roughly symmetrical neuropathy in your feet and legs which may be due to the diabetes you also noted. I have found a few things that I believe may have retarded my symmetrical PN, but I am not proposing you use these, merely responding to your request for info on my personal experience. I look for things that have shown some experimental and, in some cases, clinical evidence of having beneficial effects on the most fundamental biological mechanisms that clearly impinge on the neurological and vascular systems, e.g. endothelial function, endoplasmic reticulum function, etc. Among these supplements are TUDCA, gallic acid, ursolic acid, myo-inositol, berberine, among others. Interestingly, these all have an impact on glycemic control, as well. Most idiopathic neuropathies, in my view, and in the view of many researchers, are most likely due to glycemic dysfunction, the damage from which is difficult to reverse even after the hyperglycemia is controlled, especially since it typically flies under radar for a long time before being recognized and treated. I blame this, in part, on our current over-reliance on HbA1c, which misses a very significant number of diabetic cases, providing false security. The old two hour OGTT (oral glucose tolerance test) , once the gold standard, is still better, in my opinion. If you look at the literature you will see that there are several researchers who agree with me on this. We have sacrificed a lot for the ease of the HbA1c, trading accuracy for convenience. The OGTT is a cumbersome, time consuming test and has to be repeated to provide a clear cut diagnoses of diabetes (per the American Diabetic Association, etc.) but, in my view, is well worth it. HbA1c may have some utility for monitoring once diabetes has been thus diagnosed. For those who disagree I urge a thorough review of the literature on this.