Connect
← Return to Bone turnover markers (CTX and P1NP): do you have a baseline?
Discussion
Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: 6 hours ago | Replies (197)Comment receiving replies
@mayblin
Looking back over this discussion , to refresh my memory as I will go in AM for new labs, including bone markers. I have been on Tymlos about five months now. Our insurance with employer changed in the new year, and so far they are declining my need for an annabolic and will only cover a bisphosonate. My doc left for another part of the country, and the doc in practice I will now see wants testing to determine if “Tymlos is even working” (which is reasonable!). BUT my pen expires tomorrow, and I can’t get in to see the doc that is new to me, until mid February. So unless something wonderful happens in all the communications with insurance, or my scores wow the doc and they agree to give me a sample pen to keep me going while it’s worked out (and prior to appointment), I will be off med for at least a month. (I am willing to try to self pay generic Forteo, so hopefully doc will prescribe if labs support). This is so frustrating! Praying labs are great!
Replies to "@mayblin Looking back over this discussion , to refresh my memory as I will go in..."
I was in a similar situation last year when Cigna cut off my prior authorization for Tymlos after 4 months. I was off all medication for nearly three months until I could start teriparatide. My doctor was unconcerned and didn’t think this was a problem.
Connect
Hi @babbsjoy did you have a btm baseline, and btm labs during month 1-5 tymlos therapy? If so, any indication of anabolic effect from these data can serve as evidence that tymlos is working and should be sufficient to show your new endo imo. For some people, the biggest change in p1np is in early months 1-3 while on tymlos. It's also wise to get one done as you planned since btms most likely will change (in opposite direction) after you stop involuntarily.
I have read studies where btms ebbed and flowed with intermittent dosing of forteo (3mo on 3mo off); the resulting bmd changes at the end of study was just a bit shy of the regular daily dosing. Tymlos acts similar to Forteo, so hopefully btms and bmd outcome would be similar with interruption of the dosing, as in your case.
Hope other members who had similar dosing interruptions will chime in with experiences and outcomes. For the timebeing, take it easy - things will work out one way or the other. Keep us posted.