The course of treatment is determined by several factors and you should ask your oncologist about these, including location of tumor stage, and the genetic markers are especially important as related to whether immunotherapy or chemo is pursued. It's very important that your oncologist be on top of the most recent research because for example new research shows that chemo is not required for the Stage 3 colorectal cancer if ctDNA tests are negative 30 days post-surgery. Much depends on the institution as well because certain clinics will follow a certain approach. Specifically regarding immunotherapy, Data shows that some cancers do not respond well and that is why it is sometimes not chosen. It is not a magic bullet. Hope that helps. As a researcher myself it was very helpful to be able to ask specific questions about the most recently published studies but of course not every patient is in that situation.