Speaking of the annoying side effects of prednisone, the most annoying side effect to me is muscle problems. I've been a runner for almost 50 years, but now if I even think about running a muscle in my legs will strain. So I've had to give up on strenuous exercise for the time being.

Also, this side effect might be minor, but it really annoys me, and that's the taste and smell of prednisone. I taste it almost constantly. It's kind of metallic, and also kind of medicinal. Plus I smell it fairly often on my skin and in the air around me. It might just be a problem with my sense of smell being affected by the prednisone.

I'm currently at 10 mg a day, having tapered down from 60. The muscle problems started once I got under 20 mg a day. I don't know why they started then. Maybe it was just the amount of time I had been taking prednisone, or maybe the cumulative dose.