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ADT paradox study.

Prostate Cancer | Last Active: Jan 15 9:09am | Replies (20)
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@northoftheborder

That seems highly speculative (and not, as far as I can tell, what the article you shared is suggesting). It's possible that they might discover anything in the future, of course.

In the meantime, the most-effective currently-proven way to delay or prevent castrate resistance is to combine ADT with a second-generation ARSI like Apalutamide or Enzalutamide.

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Replies to "That seems highly speculative (and not, as far as I can tell, what the article you..."
heavyphil | @heavyphil | Jan 12 7:15am

I would agree that the article is NOT saying that. And “dogma” can sometimes be a good thing since in the medical field it is based on countless outcomes supported by facts.
It is KNOWN that testosterone can fuel prostate cancer; it is KNOWN that Prostate cancer can become castrate resistant.
But if you don’t follow the dogma - the facts - what would be your alternate course of action? No ADT? T supplements for a highly speculative already castrate resistant strain of PCa? No doctor would ever agree to that.
May I make a suggestion? Why not go with the dogma for now and see what happens. If your PSA drops and stays very low during the course of treatment, you’ll absolutely know that you are on the right path. If, however, your PSA starts to noticeably rise you can then make the course correction - if your doctors agree - to take an ADT holiday and see if the PSA comes down….or goes even higher. That can happen as well.
You are not going to cause yourself to have a fatal outcome by going on ADT for a short period of time, if that is your main worry.

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