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Prostate Cancer | Last Active: Dec 7, 2025 | Replies (21)
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I think the confusion comes from use of the word "low."
What they mean is that prostate cancer can thrive EVEN in a low-testosterone environment, not EXCLUSIVELY in a low-testosterone environment.
In other words, prostate cancer can be feeding on testosterone even when your T is 3 or 4, not just when it's 20+.
I actually asked my oncologist about this at our last appointment in November, because my T had risen to 1.2, and he said that they don't worry about it feeding the cancer until it goes over 2.0 (normal range is 6.7 to 25.7 at my lab).
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That’s the crux of the question. If this tumor was able to establish in a naturally low testosterone environment, wouldn’t cutting off the testosterone tap cause it find alternatives even more aggressively and thus, become more aggressive as a tumor - I.e more castrate resistant, and is ADT deprivation the right strategy? The consensus seems to be to follow dogma.