I initially self-diagnosed because I had the exact symptoms of PMR and was unable to see a rheumatologist immediately so I took the methylprednisolone that I had for my knee problem. It worked within the hour to remove my pain and stiffness. Upon seeing the Rheumy I was prescribed regular prednisone and noticed it was not as effective as methyprednisolone, so I asked my Rheumy to please give me a script for methylprednisolone and she did. In addition, I am on a FB Page called "Living With PMR". There are members from Canada, UK and Australia. Their Drs prescribe PREDNISOLONE. The Prednisolone does not have to get converted in your liver. The PREDNISONE must first go to your liver to get converted to PREDNISOLONE. That may be another advantage by keeping your liver out of this.