After chemo and radiation and 8 months after starting AIs and Prolia I developed knee pain that within a few months became debilitating. I started using collagen supplements. I started with gummies, then powder and am currently taking capsules. The results were amazing. I can't point a finger at AIs (I've been on all 3) or Prolia so I don't know which caused the pain originally. All I know is what worked for me. I'm 70 and do have some mild osteoarthritis and osteopenia.